Bionaturis (ticker BNT) scientists have analyzed the situation on protection against this disease which, unfortunately, is on the news in recent weeks. Based on the antigenic capacity in murine models of the glycoprotein of the Ebola virus capside (S1090, Journal of Infection Diseases, 2011:204 – Suppl. 3-, Tsuda et to the), Bionaturis team could develop a recombinant vaccine in its FLYLIFE system. Bionaturis would follow similar strategies already successfully used for other vaccine developments based on this type of protein within the company.

According to Dr Juan Jose Infante, CSO of the company, “there are data showing that, properly presented, this antigen may confer protection against the Ebola virus in healthy patients. Bionaturis has the track record and necessary knowledge in recombinant antigen presentation to pursue a high rate of success. On the other hand, unlike other options being considered, such as the use of an attenuated virus to carry this protein, a recombinant vaccine strategy would be much more safer during the production and handeling and would have less uncertainty regarding safety in healthy vaccinated humans. In the event of a successful development using FLYLIFE, thanks to its features, Bionaturis could release batches of million doses within four weeks upon order receipt. Dealing with any emergency the population at risk would be protected, guaranteeing total safety for the rest”.

Bionaturis scientists estimate that within a maximum of 24 months it would be viable to deliver experimental doses of a hipothetical  new vaccine, with proven safety and efficacy tested in animal models and ready to be tested in primates and humans, or to be used in cases of emergency as the occurred in the last month. Bionaturis´team is evaluating the possibilities of development of this vaccine along with its commercial and technological partners. A global sponsor would be needed to go through the whole regulatory process and move this vaccine forward to the patients.

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